Christina Applegate, who has been experiencing a number of sclerosis (MS) signs for a while, lately opened up concerning the bodily modifications introduced on by the progressive immune dysfunction.

Throughout an episode of the “MeSsy” podcast on Tuesday, August 20, which she co-hosts with actor Jamie-Lynn Sigler, Applegate used a particular youngsters’s e-book character to explain how her physique has modified.

“I’ve no muscle tissue in my legs, which I confirmed you,” Applegate, 52, advised Sigler. “I appear to be Humpty Dumpty. My little tiny, bizarre legs after which my huge menopausal stomach.”

Sigler, 43, who was identified with MS in 2001 on the age of 20, shared that the dysfunction has pressured her to turn out to be a “homebody,” a big shift from her as soon as energetic and athletic way of life.

“I used to be probably the most energetic, athletic — if everybody was going to go play a sport, I used to be in it until the tip,” Sigler recalled. “If everybody was going to go for a stroll, I used to be the primary one to be out on the street. That was me, that was my character. That was my life. I simply all the time needed to be doing one thing, and up and out, I used to be by no means dwelling. Now I really feel like I’m all the time dwelling.”

Applegate, in distinction, admitted that she has all the time been extra of a homebody, preferring the consolation of her mattress. Nonetheless, the development of MS has made her much more reliant on staying in.

“I like being dwelling now as a result of, nicely, I like being in my mattress, but additionally I don’t wish to be in my mattress,” she stated. “However as soon as I do exit, I’m completely happy I’ve finished it.”

Applegate defined that her buddies now perceive her limitations and don’t anticipate bodily demanding actions, equivalent to mountaineering. “That’s not going to occur as a result of I’m so not conditioned proper now,” she stated, including that the dearth of bodily exercise has left her feeling deconditioned, making even small exertions like strolling uphill really feel overwhelming.

In step with the title of their podcast episode, “I Love When Individuals Cancel,” Applegate talked about that she asks her buddies for “grace” in case she must “cancel proper earlier than” plans to hang around.

MS is a illness by which the physique’s immune system assaults the mind and spinal wire, resulting in signs equivalent to muscle stiffness and difficulties with strolling and speaking.

The Anchorman, Married With Youngsters, and Dangerous Mothers star beforehand mentioned her insecurities about ageing and her look throughout an August 1 episode of the podcast.